#05094: Doxcycline-inducible and brain-specific HIV-1 Tat transgenic mice
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TECH FIELD(S)
Research Tool
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FEATURES
Human immunodeficiency virus type 1 (HIV-1) Tat protein has been implicated in the pathogenesis of a number of AIDS-related disorders including HIV-induced neuropathogenesis. However, most of the studies demonstrating Tat neurotoxicity have been performed in vitro. The mechanisms of Tat neurotoxicity should be addressed in the context of a whole organism and in a manner that allows for characterization of pathologies specific to Tat expression in the brain. Indiana University researchers have developed a doxycycline-inducible brain-specific (GFAP promoter) Tat transgenic mouse model.
Ref: Am J Pathol. 2003 May;162(5):1693-707.
Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycycline.
Kim BO, Liu Y, Ruan Y, Xu ZC, Schantz L, He JJ.
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BENEFITS
These transgenic mice offer an in vivo model for delineating the molecular mechanisms of Tat neurotoxicity
These transgenic mice offer a tool for developing and evaluating therapeutic strategies for treating HIV-associated neurological disorders
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INVENTOR(S)
Johnny J. He, Ph.D.
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INTELLECTUAL PROPERTY STATUS
Non-patented research tool
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CONTACT INFORMATION
For additional information on this technology, please contact Rebecca Lyon, Ph.D., Associate Director of Life Sciences, IURTC:
Indiana University Research & Technology Corporation
351 West 10th Street
Indianapolis, IN 46202
Telephone: 317.278.1916
Fax:(317) 274-5902
rlyon@iu.edu
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