#06223: Light-Inducible Prokaryotic Gene Expression System
A light activated expression system to precisely control the timing and level of gene expression in prokaryotes
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TECH FIELD(S)
Novel Gene and Protein Expression Systems
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FEATURES
A light inducible gene expression system is a more precise regulator of protein expression. It can be completely induced to express product at significant yield. And, it can also be completely repressed to avoid low-level expression. The light is completely neutral to the cell and has no deleterious or biochemical altering effects.
Original transcriptional regulatory system is moved from Cyanobacteria to E. Coli. Regulation of expression is photoreceptor controlled.
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BENEFITS
- IPTG or other costly chemical inducers of expression are unnecessary
- Applications of interest include highly tunable and sustainable expression of proteins, including toxic proteins, high yield expression and potential for sequential expression of multiple protein products.
- Precise regulation of the system by application of specific wavelengths of light allows fast and complete induction and repression of transcription.
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INVENTOR(S)
David Kehoe – Department of Biology, Associate Professor
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INTELLECTUAL PROPERTY STATUS
PCT application available for licensing
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CONTACT INFORMATION
For additional information on this technology, please contact Doug Bodde, Business Development Manager, IURTC:
Indiana University Research & Technology Corporation
351 West 10th Street
Indianapolis, IN 46202
Telephone: 812.855.1608
dbodde@iu.edu
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