#07153: Disease Diagnosis by Profiling of Serum Glycans
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TECH FIELD(S)
Medical-Biomarkers
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FEATURES
A distinct goal in cancer diagnosis has been detecting cancer-related changes in patient's blood. Some recently identified cancer biomarkers in human serum are glycoproteins. However, this approach has been less commonly pursued due to the difficulties with high-sensitivity measurements of glycans.
This invention utilizes a MS-based glycomic profiling of serum-derived constituents to provide a highly sensitive and informative approach to differential evaluation of cancer conditions. For a description of the inventions, see the inventor's web site: http://www.indiana.edu/~novweb/?page=glycomics
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BENEFITS
- Successfully distinguished different cancer stages and disease-free condition, for both breast cancer and prostate cancer.
- Non-invasive methodology - only a small volume of blood serum needed, without biopsy or tumor removal.
- Provided a highly sensitive and statistically significant result.
- Inexpensive
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INVENTOR(S)
Milos V. Novotny, PhD - Indiana University, Department of Chemistry
Yehia Mechref, PhD - Indiana University, Department of Chemistry
Zuzana Kyselova - Indiana University, Department of Chemistry
Pilsoo Kang - Indiana University, Department of Chemistry
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INTELLECTUAL PROPERTY STATUS
US provisional patent pending
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CONTACT INFORMATION
Bill L. Brizzard, Ph.D.
Director of Technology Transfer IURTC
501 North Morton Street Suite 204
Bloomington, IN 47404
Phone: (812) 855-3597
Fax: (812) 855-3728
bbrizzar@iu.edu
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